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doi:10.1177/0194599820909438 Barkwill D, Arora R

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Histone demethylation by a family of JmjC domain-containing proteins

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reviewed in Ansari et al., in vitro and in vivo models of aging (Anamika et al., Sirt3/ mouse embryonic fibroblasts induced abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and increased genomic instability (Kim et al., Sirt3 is the third most expressed member of the sirtuin family in the whole brain of the adult rat, except in the cerebellum where its expression was modestly lower (Sidorova-Darmos et al., Sirt3 was similar in cortex, cerebellum and hippocampus, with Sirt3 mRNA levels being fairly consistent from embryonic day 18 (E18) until 24 months of age (Sidorova-Darmos et al., Sirt3 mRNA levels were similar at least in liver tissue from male and female mice at the age of 11 months (Yu et al., The co-presence of SIRT3 and the peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) implicates its role in mitochondrial biogenesis that provides ATP to support fundamental cellular processes involved in synaptic plasticity such as neurite outgrowth (Kong et al., 3

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